Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 37 Researches
8.1
USERS' SCORE
Good
Based on 143 Reviews
8.4
Supplement Facts
Serving Size:  1 Capsule
Amount Per Serving
%DV
Proprietary Probiotic Blend 
134 mg (1 Billion CFU§)
Lactobacillus rhamnosus (GR-1®) 
 
 
Lactobacillus reuteri (RC-14®) 
 
 

Top Medical Research Studies

9
Lactic acid bacteria inhibit Candida albicans
We explored how lactic acid bacteria (LAB) can combat the harmful effects of Candida albicans, the fungus responsible for yeast infections. Through our study, we found that the supernatant from LAB like Lactobacillus crispatus and L. gasseri effectively inhibited the growth and harmful activity of C. albicans.

Specifically, L. gasseri showed exceptional ability in preventing the formation of biofilms and hyphae, crucial stages in fungal development. Additionally, the metabolites produced by these bacteria downregulated key genes associated with C. albicans, reinforcing their role in maintaining vaginal health.

Overall, while the findings are promising, further research is needed to confirm the clinical effectiveness of these metabolites in treating or preventing yeast infections.
Read More
We explored how Limosilactobacillus fermentum KBL674 impacts vaginal candidiasis, commonly caused by Candida albicans. In a mouse model, this probiotic strain significantly inhibited C. albicans growth and alleviated symptoms like tissue swelling and immune response. Interestingly, many of the administered L. fermentum KBL674 didn't remain in the gut; it altered gut bacteria diversity, linking these changes to reduced yeast infection severity. Overall, our findings suggest that L. fermentum KBL674 may offer a promising approach to help manage yeast infections.
Read More
8
Lactobacillus maintains microbiota balance
We investigated how lactobacillus probiotics could restore the vaginal and gut microbiota of pregnant women dealing with vaginal candidiasis. In a well-structured randomized study with 78 participants, we compared a probiotic with a placebo over eight weeks.

Our findings showed that those receiving the probiotic had stable microbiota, unlike those on the placebo, who experienced significant shifts. This suggests lactobacillus can help maintain a healthy microbial balance, which is essential for health during pregnancy. Overall, lactobacillus probiotics offer promising benefits in managing yeast infections.
Read More

Most Useful Reviews

9
Chronic yeast infection relief
475 people found this helpful
Kicked a chronic yeast infection! Instead of using antifungals, probiotics were my answer. I struggled for almost four months with a stubborn infection, tested for various conditions, but nothing helped. I previously used Culturelle without success for my yeast infection because it doesn't colonise the vaginal tract. Femdophilus is the game-changer—it has the right strains. After both oral and vaginal use, relief was almost immediate, and I plan to continue it long-term.
Read More
9
Significant health difference.
178 people found this helpful
This is such a life saviour. After battling BV throughout my second pregnancy, I found that antibiotics were ineffective. Since starting these probiotics, I have seen a significant health improvement, along with dietary changes. If you're fighting BV or yeast infections, I urge you to try this; it can truly change your life!
Read More
9
No more infections
163 people found this helpful
The capsules are small and easy to take. These are a true life saver! After battling constant yeast and bacterial infections for years, I decided to try this probiotic. I took it daily and, incredibly, I haven’t had an infection again for almost a year! I'm being proactive and purchased another bottle just in case. They’ve never upset my stomach, making them absolutely worth it!
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 37 Researches
8.1
  • All Researches
9.5
Lactobacillus gasseri shows promise
We investigated the potential of a specific strain of Lactobacillus gasseri, named VHProbi E09, to treat vaginitis and fight off common pathogens causing yeast infections. Through laboratory tests, we found that this strain effectively inhibited the growth of harmful bacteria and yeast by over 99%.

Additionally, it prevented these pathogens from adhering to vaginal cells, showing promise for future clinical applications. While these results are promising, further research is necessary to fully understand its effectiveness in clinical settings and its role in restoring normal vaginal flora.
Read More
We investigated how Lactobacillus rhamnosus Lcr35, contained in the GYNOPHILUS product, can combat yeast infections like Candida. This study showed that the product’s formulation, enhanced by sodium thiosulfate, improves its ability to kill yeast cells.

Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.

Interestingly, achieving the full antifungal impact relies on these sulfur components.
Read More
9
Novel yeast infection treatment studied
We examined a new treatment, VAGINNE, derived from beneficial species to tackle vulvovaginal candidiasis (VVC). Using a mouse model, we observed that VAGINNE improved the balance of the vaginal microbiome while reducing harmful yeast growth.

Additionally, it lowered inflammatory markers in both vaginal tissue and blood, suggesting an anti-inflammatory effect. Our histological analysis showed better tissue integrity in treated mice compared to those without treatment.

These results indicate that VAGINNE can be a promising, side-effect-free alternative to conventional antifungals for managing VVC, especially in cases where drugs fail or cause issues.
Read More
9
Probiotics enhance yeast infection treatment
We aimed to understand if adding probiotics to standard antifungal treatment improves outcomes for vulvovaginal candidiasis (VVC). In our study, 60 women diagnosed with VVC were divided into two groups.

One group received just antifungal medication, while the other received both antifungal and probiotic treatments.

Results indicated that those who took probiotics alongside their antifungal showed better improvement and had lower relapse rates. This suggests that probiotics can be a beneficial addition to standard yeast infection treatments.
Read More
9
Lactic acid bacteria inhibit Candida albicans
We explored how lactic acid bacteria (LAB) can combat the harmful effects of Candida albicans, the fungus responsible for yeast infections. Through our study, we found that the supernatant from LAB like Lactobacillus crispatus and L. gasseri effectively inhibited the growth and harmful activity of C. albicans.

Specifically, L. gasseri showed exceptional ability in preventing the formation of biofilms and hyphae, crucial stages in fungal development. Additionally, the metabolites produced by these bacteria downregulated key genes associated with C. albicans, reinforcing their role in maintaining vaginal health.

Overall, while the findings are promising, further research is needed to confirm the clinical effectiveness of these metabolites in treating or preventing yeast infections.
Read More

User Reviews

USERS' SCORE
Good
Based on 143 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Chronic yeast infection relief
475 people found this helpful
Kicked a chronic yeast infection! Instead of using antifungals, probiotics were my answer. I struggled for almost four months with a stubborn infection, tested for various conditions, but nothing helped. I previously used Culturelle without success for my yeast infection because it doesn't colonise the vaginal tract. Femdophilus is the game-changer—it has the right strains. After both oral and vaginal use, relief was almost immediate, and I plan to continue it long-term.
Read More
9
Significant health difference.
178 people found this helpful
This is such a life saviour. After battling BV throughout my second pregnancy, I found that antibiotics were ineffective. Since starting these probiotics, I have seen a significant health improvement, along with dietary changes. If you're fighting BV or yeast infections, I urge you to try this; it can truly change your life!
Read More
9
No more infections
163 people found this helpful
The capsules are small and easy to take. These are a true life saver! After battling constant yeast and bacterial infections for years, I decided to try this probiotic. I took it daily and, incredibly, I haven’t had an infection again for almost a year! I'm being proactive and purchased another bottle just in case. They’ve never upset my stomach, making them absolutely worth it!
Read More
9
Year-long infection resolved
37 people found this helpful
Year-long yeast infection GONE! I had an ongoing yeast infection for almost a year caused by candida glabrata, resistant to most treatments. I utilized various remedies with no success. I finally began taking these probiotics and introduced a diet change while also using diflucan sporadically. Maintaining good hygiene helped too, and now, after two weeks, I’m infection-free. I’m continuing this regimen for maintenance, and I’m incredibly thankful to have finally dealt with the root cause of my recurrent yeast infection.
Read More
9
Relief on third day
37 people found this helpful
I wish I could give this more stars! Like many women here, I have experienced chronic yeast infections and BV issues, particularly while on antibiotics for Boils. After just three days of taking this product, I noticed a remarkable difference—no more itching and the funny odour is gone! I cannot express how happy I am; every woman knows how unsexy it feels when things aren't right down there. My confidence is regained, and I will definitely let other women know about this incredible product! However, I did notice I seemed to urinate more, but I’m not certain if that was due to the medication. I will be purchasing more!
Read More

Frequently Asked Questions

9
Effective treatment
6 people found this helpful
It is highly effective for Candida infections. I took three tablets every three hours during the infection, and it improved significantly within three days. Along with vitamin C and healthy habits, I found it works well. The capsules are small and easy to swallow—I have repurchased them multiple times.
9
Positive response
6 people found this helpful
Best women's prebiotics! I've dealt with yeast infections, itching, and bloating. After two weeks of use, I'm experiencing relief—no itching, no discharge, and no yeast infections. It also helps with bloating. The price is higher, but I will continue using it regularly despite needing to refrigerate it.
10
Candidiasis solved
4 people found this helpful
My friend recommended this. Probiotics can reduce yeast infections in various organ systems. This product resolved my Candidiasis issue. I’ve been using it for three months and my problem is solved.
10
Odour elimination
18 people found this helpful
The unpleasant odour I had experienced for decades vanished overnight after taking this supplement. No more itching; it's truly a miracle for my confidence!
9
Thrush relief
29 people found this helpful
My salvation! I had little hope for this probiotic, but after just two months, my recurrent yeast infection and its unpleasant symptoms have vanished. Despite the high cost, it proved effective where traditional treatments failed. I wholeheartedly recommend this purchase!
9
Stubborn infection remedy
18 people found this helpful
This is the only women’s probiotic I trust. Since starting it 10 years ago, I have avoided yeast infections. For best results, take it on an empty stomach, twenty minutes before meals.
9
3-year relief
2 people found this helpful
I've been taking this consistently for three years. Stress would typically lead to vaginitis, but since using this product, I've not experienced any vaginal infections. My condition has greatly improved.
10
Long-term relief
3 people found this helpful
I bought this and another package. The taste is acceptable, and as a vegetarian, I appreciate the vegetarian capsules. My yeast infection has not recurred for four months. I also focus on work, rest, and a healthy lifestyle for best results.
9
Candida control
3 people found this helpful
I am very satisfied! This product has effectively addressed my recurring Candida infections. Even after stopping for half a year, it helped significantly during a recent flare-up. I took two capsules a day during the acute phase, and it worked wonders.
9
Infection improvement
2 people found this helpful
After suffering from ongoing mould infections for over a year, I found this to be remarkably effective. Now, I take two capsules daily during flare-ups and one for maintenance, and I've not had another attack since.
We explored how Lactobacillus rhamnosus (LR) can aid in fighting Candida infections. The study tested LR and other lactobacilli in both mouse macrophages and Galleria mellonella larvae.

Results showed that LR significantly boosted immune responses and enhanced larvae survival against Candida. In particular, it reduced yeast counts, showcasing its potential as an adjunct treatment for managing yeast infections.

Ultimately, LR stood out for its anti-Candida effects, making it a promising ally against these tough fungal threats.
7
Probiotics reduce yeast infection recurrence
We explored the effectiveness of probiotics for treating vulvovaginal candidiasis through a systematic review and meta-analysis of six randomized control trials. Our thorough search aimed to discover whether probiotics could serve as an effective treatment compared to placebo.

While probiotics didn't show a significant difference in positive culture rates, they did demonstrate a reduction in recurrence of infections. This indicates that while they may not remove the yeast directly, they can aid in preventing future flare-ups. Thus, probiotics might be a helpful option for managing yeast infections.
1
No reduction in VVI recurrence
We investigated the role of oral probiotics in preventing recurrent vulvovaginal infections (VVIs) during pregnancy. In a rigorous multicenter trial, pregnant women with previous infections received either a probiotic or placebo.

Despite the intention to enhance vaginal health, our findings revealed no significant difference in infection rates between the two groups. This indicates that the tested probiotics did not effectively lower the risk of VVIs after treatment.

Thus, for pregnant women, these specific probiotics seem to fall short in combatting recurring infections.

References

  1. Nachum Z, Suleiman A, Colodner R, Battino S, Wattad M, et al. Oral Probiotics to Prevent Recurrent Vulvovaginal Infections During Pregnancy-Multicenter Double-Blind, Randomized, Placebo-Controlled Trial. Nutrients. 2025;17. doi:10.3390/nu17030460
  2. Horng HC, Xu JW, Kuo YS, Chen YS, Chiu YH, et al. Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of Fermentation Broth in Treating Vulvovaginal Candidiasis. J Fungi (Basel). 2024;11. doi:10.3390/jof11010018
  3. Thekho AJ, Mendiratta V, Garg T, Kaur R, Yadav V. Role of Probiotic in Vulvovaginal Candidiasis: A Randomised Controlled Non-blinded Trial from India. Indian J Dermatol. 2024;69:422. doi:10.4103/ijd.ijd_193_24
  4. Bae WY, Lee YJ, Jo S, Shin SL, Kim TR, et al. Effects of LM1215 on and . Yonsei Med J. 2024;65:727. doi:10.3349/ymj.2023.0490
  5. Jang SJ, Jo EJ, Lee C, Cho BR, Shin YJ, et al. Limosilactobacillus fermentum KBL674 Alleviates Vaginal Candidiasis. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10403-3
  6. Vazquez-Munoz R, Thompson A, Sobue T, Dongari-Bagtzoglou A. is a dominant in the murine oral mucosa and has chitinase activity that compromises fungal cell wall integrity. mBio. 2024;15:e0241624. doi:10.1128/mbio.02416-24
  7. Zhang J, Li K, Cao T, Duan Z. Characterization of a Lactobacillus gasseri strain as a probiotic for female vaginitis. Sci Rep. 2024;14:14426. doi:10.1038/s41598-024-65550-y
  8. Elsayes SA, El Attar MS, ElHadary A, Aboulela AG, Essawy MM, et al. Antimycotic prophylaxis with multispecies probiotics against oral candidiasis in new complete denture wearers: A randomized clinical trial. J Prosthet Dent. 2024. doi:10.1016/j.prosdent.2024.05.018
  9. Zahedifard T, Khadivzadeh T, Rakhshkhorshid M. The Role of Probiotics in the Treatment of Vulvovaginal Candidiasis: A Systematic Review and Meta-Analysis. Ethiop J Health Sci. 2023;33:881. doi:10.4314/ejhs.v33i5.18
  10. Sookkhee S, Khamnoi P, Sastraruji T, Boonkum S, Wikan N, et al. Synergistic Inhibition of Synbiotic Cultures among Lactobacilli and Plant Extracts against Vaginal Discharge Causing . Nutrients. 2024;16. doi:10.3390/nu16091372
  11. Ang XY, Roslan NS, Ahmad N, Yusof SM, Abdullah N, et al. Lactobacillus probiotics restore vaginal and gut microbiota of pregnant women with vaginal candidiasis. Benef Microbes. 2023;14:421. doi:10.1163/18762891-20220103
  12. Bertarello C, Savio D, Morelli L, Bouzalov S, Davidova D, et al. Efficacy and safety of Lactobacillus plantarum P 17630 strain soft vaginal capsule in vaginal candidiasis: a randomized non-inferiority clinical trial. Eur Rev Med Pharmacol Sci. 2024;28:384. doi:10.26355/eurrev_202401_34927
  13. Faustino M, Pereira JO, Pereira AM, Oliveira AS, Ferreira CMH, et al. Vaginal prevention of Candida albicans: synergistic effect of lactobacilli and mannan oligosaccharides (MOS). Appl Microbiol Biotechnol. 2024;108:73. doi:10.1007/s00253-023-12909-2
  14. Das S, Konwar BK. Inhibiting pathogenicity of vaginal Candida albicans by lactic acid bacteria and MS analysis of their extracellular compounds. APMIS. 2024;132:161. doi:10.1111/apm.13365
  15. Deshkar S, Yeole P, Mahore J, Shinde A, Giram P. Polyelectrolyte-Complex-Based Hydrogel Inserts for Vaginal Delivery of Posaconazole and Probiotics. Gels. 2023;9. doi:10.3390/gels9110851
  16. ElFeky DS, Awad AR, Shamseldeen AM, Mowafy HL, Hosny SA. Comparing the therapeutic potentials of vs. against vulvovaginal candidiasis in female rats: an study. Front Microbiol. 2023;14:1222503. doi:10.3389/fmicb.2023.1222503
  17. Chantanawilas P, Pahumunto N, Thananimit S, Teanpaisan R. Anticandidal Activity of Various Probiotic Lactobacillus Strains and Their Efficacy Enhanced by Prebiotic Supplementation. Curr Microbiol. 2024;81:271. doi:10.1007/s00284-024-03800-y
  18. Pimentel MMNSC, de Carvalho Alves J, Pinheiro LHS, Roselino MN. Potential Action of Probiotics Against Fungi of the Genus : A Bibliographic Review. Recent Pat Biotechnol. 2023;17:198. doi:10.2174/1872208317666221027093644
  19. Spaggiari L, Sala A, Ardizzoni A, De Seta F, Singh DK, et al. Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System . Microbiol Spectr. 2022;10:e0269621. doi:10.1128/spectrum.02696-21
  20. Dausset C, Bornes S, Miquel S, Kondjoyan N, Angenieux M, et al. Identification of sulfur components enhancing the anti-Candida effect of Lactobacillus rhamnosus Lcr35. Sci Rep. 2020;10:17074. doi:10.1038/s41598-020-74027-7
  21. Kumherová M, Veselá K, Kosová M, Mašata J, Horáčková Š, et al. Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections. Probiotics Antimicrob Proteins. 2021;13:163. doi:10.1007/s12602-020-09675-2
  22. Poupet C, Saraoui T, Veisseire P, Bonnet M, Dausset C, et al. Lactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the invertebrate model Caenorhabditis elegans: First mechanistic insights. PLoS One. 2019;14:e0216184. doi:10.1371/journal.pone.0216184
  23. Lee X, Vergara C, Lozano CP. Severity of Candida-associated denture stomatitis is improved in institutionalized elders who consume Lactobacillus rhamnosus SP1. Aust Dent J. 2019;64:229. doi:10.1111/adj.12692
  24. De Gregorio PR, Silva JA, Marchesi A, Nader-Macías MEF. Anti-Candida activity of beneficial vaginal lactobacilli in in vitro assays and in a murine experimental model. FEMS Yeast Res. 2019;19. doi:10.1093/femsyr/foz008
  25. Leão MVP, Tavares TAA, Gonçalves E Silva CR, Dos Santos SSF, Junqueira JC, et al. Lactobacillus rhamnosus intake can prevent the development of Candidiasis. Clin Oral Investig. 2018;22:2511. doi:10.1007/s00784-018-2347-8
  26. Rossoni RD, Dos Santos Velloso M, Figueiredo LMA, Martins CP, Jorge AOC, et al. Clinical strains of Lactobacillus reduce the filamentation of Candida albicans and protect Galleria mellonella against experimental candidiasis. Folia Microbiol (Praha). 2018;63:307. doi:10.1007/s12223-017-0569-9
  27. Tan Y, Leonhard M, Moser D, Ma S, Schneider-Stickler B. Inhibitory effect of probiotic lactobacilli supernatants on single and mixed non-albicans Candida species biofilm. Arch Oral Biol. 2018;85:40. doi:10.1016/j.archoralbio.2017.10.002
  28. Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, et al. Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLoS One. 2017;12:e0184438. doi:10.1371/journal.pone.0184438
  29. de Oliveira FE, Rossoni RD, de Barros PP, Begnini BE, Junqueira JC, et al. Immunomodulatory effects and anti-Candida activity of lactobacilli in macrophages and in invertebrate model of Galleria mellonella. Microb Pathog. 2017;110:603. doi:10.1016/j.micpath.2017.08.006
  30. Boahen A, Chew SY, Neela VK, Than LTL. Limosilactobacillus reuteri 29A Cell-Free Supernatant Antibiofilm and Antagonistic Effects in Murine Model of Vulvovaginal Candidiasis. Probiotics Antimicrob Proteins. 2023;15:1681. doi:10.1007/s12602-023-10050-0
  31. Mezzasalma V, Manfrini E, Ferri E, Boccarusso M, Di Gennaro P, et al. Orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study. Arch Gynecol Obstet. 2017;295:163. doi:10.1007/s00404-016-4235-2
  32. Kraft-Bodi E, Jørgensen MR, Keller MK, Kragelund C, Twetman S. Effect of Probiotic Bacteria on Oral Candida in Frail Elderly. J Dent Res. 2015;94:181S. doi:10.1177/0022034515595950
  33. Chew SY, Cheah YK, Seow HF, Sandai D, Than LT. Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 exhibit strong antifungal effects against vulvovaginal candidiasis-causing Candida glabrata isolates. J Appl Microbiol. 2015;118:1180. doi:10.1111/jam.12772
  34. Oncel MY, Arayici S, Sari FN, Simsek GK, Yurttutan S, et al. Comparison of Lactobacillus reuteri and nystatin prophylaxis on Candida colonization and infection in very low birth weight infants. J Matern Fetal Neonatal Med. 2015;28:1790. doi:10.3109/14767058.2014.968842
  35. Wagner RD, Johnson SJ. Probiotic lactobacillus and estrogen effects on vaginal epithelial gene expression responses to Candida albicans. J Biomed Sci. 2012;19:58. doi:10.1186/1423-0127-19-58
  36. Martinez RC, Seney SL, Summers KL, Nomizo A, De Martinis EC, et al. Effect of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on the ability of Candida albicans to infect cells and induce inflammation. Microbiol Immunol. 2009;53:487. doi:10.1111/j.1348-0421.2009.00154.x
  37. Martinez RC, Franceschini SA, Patta MC, Quintana SM, Candido RC, et al. Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Lett Appl Microbiol. 2009;48:269. doi:10.1111/j.1472-765X.2008.02477.x
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